Larger buffer sizes for non time critical processing?

I understand 512 bytes (10ms) is probably the limit for live effects, but what about having buffer sizes in the range 1024-4096 for non time critical processing such as send effects, mastering and using (for example) DAWs as inputs to Audiobus? As I understand, Audiobus compensates for the latency anyway, assuring the audio stream is in sync regardless.
Larger buffer sizes would mean less CPU load and a wider span of available complex synths and effects. Wohooo! :)
(something tells me it's not that simple, though..)

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